Nov 262011

How Does Metformin And Other Anti Diabetic Drugs Interact With Food?

Most individuals suffering from Type 2 Diabetes think that food only contains fats, proteins, and carbohydrates. This is definitely not true.

Foods, especially those that originate from plants, possess different chemical compounds that also interact with the enzymes present in the liver. These enzymes are the very ones that are also used by the liver to destroy and detoxify active chemicals that are present in the medications you take to control diabetes. It would be advantageous to be able to discover which type of foods are able to recycle the active ingredients present in diabetes medications as well as which type of foods can slow it down as these will affect the rise and the dip of blood sugar levels.

How the food you eat will affect the diabetes medication you take in will depend on what enzyme is used by your liver. This is an overview of the interactions of several medications that are typically used to treat Type 2 Diabetes and how the food you eat affects how the liver will process them.

  1. Metformin, which is also known as Glucophage is one medication that does not get processed by the liver. This means the use of Metformin cannot be affected by the food you eat.
  2. Vildagliptin, which is also known as Galvus is a diabetes medication that is processed by the liver with cytochrome P450. However, the processing is very limited. Through consuming licorice, grapefruit, ginger, or hot peppers, you can increase the ability of this medication to decrease blood sugar levels in the body.
  3. Sitagliptin, which is also known as Januvia gets processed in the liver with the CYP2C8 and CYP3A4 enzymes. Avoid eating too much fruit and drinking fruit juices as these will interfere with the enzymes and they will increase the possibility of acquiring the side effects caused by the medication. When using Sitagliptin, you should avoid the consumption of mangoes, oranges, dragon fruits, rambutans, passion fruits, pawpaws, wild grapes, pomegrenates, wild mullberies, and kiwis.
  4. Pioglitazone, which is also known as Actos, is processed with the CYP2C8 enzyme. All of the fruits mentioned above will also affect this medication so it is important to avoid them especially pomegranate juice.
  5. The CYP2C8 enzyme also processes Rosiglitazone, also known as Avandia, so it is also advised to avoid the fruits mentioned earlier. The intake of promegrenate juice will also cause this medication to produce greater side effects so stay away from the fruit juice as much as possible.

Also remember that these diabetic medications will become more effective when you are following a healthy lifestyle, which includes the following:

  1. Eating the right amount of healthy foods
  2. Increased regular physical activities
  3. Reducing stress

These medications are not used to cure diabetes as the disease currently has no possible cures. Most of these medications will work for a certain period, but they will slowly lose their efficiency overtime as the body becomes immune to them. When these medications available lose their desired effect, injectable insulin might be your second best option.

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